Inhibition of Human Corneal Myofibroblast Formation
نویسندگان
چکیده
منابع مشابه
Molecular regulation of myofibroblast formation
Novel strategies are required to counteract tissue contractures characteristic for organ fibrosis, stroma reaction to tumors, host reaction to implants, and formation of hypertrophic scars as after burns. Key element for the development and progression of these pathologies is the excessive contractile force generated by a-smooth muscle actin (a-SMA)-expressing myofibroblasts. We can modulate my...
متن کاملMyofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts.
PURPOSE The purpose of this study was to determine whether TGFbeta induces myofibroblast differentiation in cultured human keratocytes and in telomerase (hTERT)-immortalized human corneal fibroblast cell lines. METHODS Normal human corneal keratocytes were isolated from donor corneas of various ages and grown under serum-free (cultured keratocytes) or serum-added (corneal fibroblasts) conditi...
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متن کاملInhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase.
Transformation of fibroblasts to myofibroblasts, characterized by expression of alpha-smooth muscle actin (alpha-SMA) and production of extracellular matrix (ECM) components, is a key event in connective tissue remodeling. Approaches to inhibit this transformation are needed in tissues, such as the heart, where excessive ECM production by cardiac fibroblasts (CFs) causes fibrosis, myocardial st...
متن کاملEffect of cAMP on TGFbeta1-induced corneal keratocyte-myofibroblast transformation.
PURPOSE TGFbeta is the major mediator to induce myofibroblast differentiation in the corneal wound-healing process. Elevated cAMP can reduce TGFbeta-induced fibrosis in other tissues. This study was conducted to determine whether elevated cAMP can inhibit TGFbeta1-induced rabbit corneal keratocyte-myofibroblast transformation. METHODS Primary isolated rabbit corneal keratocytes were cultured ...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2018
ISSN: 1552-5783
DOI: 10.1167/iovs.18-24239